Penfield ResponseChange something. See what follows.
Penfield Response studies what happens when a computational brain is perturbed. Apply an intervention to a model, run it through Dynamics, and read the predicted neural response.
It is research simulation software: a way to ask sharper questions before the laboratory, the scanner or the clinic, not a way to skip them.
Discuss response researchHow Penfield Response works
Before.
And after.
Every prediction is shown against baseline, with confidence and assumptions attached. What the software cannot support, it does not predict.
MODEL PF–001→INTERVENTION→DYNAMICS 0.2→PREDICTED RESPONSE
- Class
- CHEMICAL
- Intervention
- Propofol
- Parameters
- GABA-A positive modulator · 2 µg/mL equivalent
- Confidence
- 71%
- Regional PK approximation
- No individual variation modelled
A predicted response is a hypothesis, not a result. It informs experiments; it does not replace them.
In-silico predictions on a synthetic model. They inform experiments; they do not replace them.
Switch intervention class to comparePerturb the model,
not the patient.
Chemical
Drugs, receptor effects, neurotransmitter changes, anaesthetic effects.
Electrical / Magnetic
DBS, TMS and other stimulation paradigms.
Biological
Receptor changes, gene-related parameters, disease mechanisms.
Physiological
Oxygen, sleep, temperature and metabolic state.
Structural
Injury, lesions, tumour effects and simulated resection.
- 01Pharmaceutical research
- 02Neuroscience
- 03Neurotechnology
- 04Intervention research
Simulated response never replaces laboratory experiments, clinical trials or clinical judgement. Run in Dynamics Plan in Plan
One system
Every Penfield product sits on the same path: measurement in, intervention out. Penfield Response is one part of it.
Observe & Understand
Understand
Simulate