Penfield CompoundFrom molecule to brain response.
Penfield Compound defines the chemical environment around a computational brain (compounds, endogenous neurochemicals and physiological state) and models how they may alter its dynamics.
It sits across Understand and Simulate: it asks what changes chemically, then hands that environment to Dynamics to ask what follows. Every stage carries evidence, confidence, uncertainty and provenance.
Discuss compound researchHow Penfield Compound works
One environment.
Every stage scored.
Combine compounds and neurochemicals, then scrub time from exposure to elimination. Occupancy, network response and confidence are tracked at every step, and predictions are never shown as stronger than their evidence.
- Receptor A
- 26%
- Receptor B
- 59%
- Prefrontal
- +7%
- Striatal
- +46%
- Alpha power
- -5%
- Molecular
- High
- PK
- Moderate
- Circuit
- Low
- Whole brain
- Low
- Shared targets
- 3
- Competitive binding
- POSSIBLE
- Metabolic interaction
- MODERATE
- Network interaction
- PREDICTED STRONG
- Evidence
- MIXED
All values are illustrative. Compound informs research; it does not predict individual drug response.
Synthetic compounds and illustrative pharmacology on a synthetic model. Compound informs experiments; it does not replace laboratory testing, toxicology or clinical trials.
Scrub time, add compounds, compare scenariosNot a slider.
A state of the brain.
Exogenous
Drugs, compounds and metabolites, identified by name, SMILES, InChI or structure, and carried with their evidence grade.
Endogenous
Dopamine, serotonin, GABA, glutamate, hormones and neuromodulators, modelled as regional concentration against receptor distribution, not global sliders.
Physiological
Oxygen, CO₂, glucose, temperature and sleep state: the context a chemical environment acts inside.
External stimuli
Visual, auditory and other research stimuli, combined with chemical conditions in the same run.
Environments combine: compare A alone, B alone, A + B or A + B + C, with interactions like competitive binding, enzyme inhibition and opposing effects surfaced, never smoothed over.
Mechanistic where possible.
Learned where necessary.
Explicitly uncertain where unknown.
- 01Known
- 02Experimentally supported
- 03Computationally predicted
- 04Unknown
A predicted whole-brain response is only as strong as its weakest stage. Compound keeps that score visible. It does not replace laboratory testing, clinical trials, toxicology, pharmacology studies or clinical judgement. Targets in Atlas Model Dynamics Response
One system
Every Penfield product sits on the same path: measurement in, intervention out. Penfield Compound is one part of it.
Observe & Understand
Understand
Simulate